This research aims to develop design and fabrication methods for microbial bio-cement to create low-carbon architectural elements. Specifically, it proposes integrating living organisms into the built environment using Microbial Induce Calcium Carbonate Precipitation (MICP) as a bio-cement alternative. The bio-cement production eliminates the need for natural resource extraction and fuel sources for heating kilns, resulting in a material that resembles concrete but possesses novel functionalities such as self-repair, self-assembly, and responsiveness to environmental stimuli. Despite the potential benefits of bio-cementation, its integration into large-scale architectural applications and advanced manufacturing methods still needs to be explored. Therefore, to fully expand the potential of microbial bio-cement, this research focuses on developing a computational design framework that considers various parameters to tailor the growth of microorganisms and enhance chemical exchange while maintaining structural stability. Architectural questions related to geometry and growth behavior will be investigated using novel design and fabrication methods to create large-scale architectural components. In addition, this research intends to critically reflect on using bio-cement as an alternative building material, evaluating the potential environmental impact of living materials in the building environment.